Molecular Reagent HemeScreen® RUNX1 For Research Use Only For HRM-enabled RT-PCR Machine / Cytopenia Panel 100 Tests

Features

• Precipio’s HemeScreen® offerings are Research Use Only (RUO) assays that screen for clinically actionable somatic mutations in targets of interest related to myeloproliferative disorders and haematological cancers
• The reagents are designed to be used in a clinical diagnostic laboratory by suitably trained personnel testing DNA extracted from whole blood or bone marrow using a PCR-based method and High Resolution Melt (HRM) Analysis
• RUNX1 (runt-related transcription factor 1) mutation is commonly seen in chemotherapy-related MDS, but is also seen in MDS, AML, as well as AML after MDS
• RUNX1 mutation is also associated with abnormal cytogenetics, including monosomy 7, trisomy 21 and trisomy 13. RUNX1 and monosomy 7 can lead to rapid progression of AML when the patient is being treated for MDS; CEBPA and NPM1 are not commonly associated with mutated RUNX1
• RUNX1 mutation has a poor prognosis regardless of cytogenetic abnormalities and should be considered in the diagnosis of AML
• Free-Flow Reagent
• Each HemeScreen® reagent sets contains enough reactions for 100 samples in duplicate and includes enough Mutant control for 5 reactions
• Machine required HRM-enabled RT-PCR (example/ ThermoFisher Quantstudio 3 or higher)
• Reagent sets should be stored in the dark between -18 °C and -25 °C in a constant temperature freezer until use

More Information

• SDS